{"id":20711,"date":"2021-03-23T14:00:14","date_gmt":"2021-03-23T14:00:14","guid":{"rendered":"http:\/\/prrscontrolidiomas.advertis.es\/3-que-ocurre-en-una-granja-infectada\/"},"modified":"2021-03-26T11:08:20","modified_gmt":"2021-03-26T11:08:20","slug":"que-ocurre-en-una-granja-infectada","status":"publish","type":"page","link":"https:\/\/prrscontrol.com\/es\/epidemiologia\/que-ocurre-en-una-granja-infectada\/","title":{"rendered":"<span>3<\/span> \u00bfQu\u00e9 ocurre en una granja infectada?"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=\u00bb1\/1&#8243;][vc_column_text el_class=\u00bbintro\u00bb]Las consecuencias de una <strong>infecci\u00f3n por el virus del PRRS<\/strong> en una granja depender\u00e1n\u00a0principalmente de la <strong>virulencia<\/strong> de la cepa y del <strong>estado previo de inmunizaci\u00f3n<\/strong>.[\/vc_column_text][vc_column_text]Una vez que se introduce el virus del PRRS en una granja, este tender\u00e1 a circular\u00a0indefinidamente. La eliminaci\u00f3n espont\u00e1nea puede ocurrir, especialmente en granjas\u00a0peque\u00f1as, pero es muy rara.<\/p>\n<p>La presencia de una <strong>infecci\u00f3n persistente<\/strong> en animales\u00a0portadores, la presencia de subpoblaciones negativas en el hato reproductor y\/o un flujo\u00a0continuo de animales susceptibles pueden perpetuar la infecci\u00f3n: reposici\u00f3n negativa\u00a0insuficientemente inmunizada, nacimiento de lechones de cerdas seronegativas, p\u00e9rdida\u00a0de inmunidad pasiva en lechones o p\u00e9rdida de inmunidad activa en cerdos previamente\u00a0infectados.<\/p>\n<p>Por ejemplo, la seroprevalencia en cerdas durante un brote agudo nunca\u00a0alcanza el 100%. As\u00ed, un porcentaje variable de cerdas se escapan de la infecci\u00f3n inicial,\u00a0pero m\u00e1s tarde seroconvierten, lo que indica que las <strong>subpoblaciones negativas<\/strong> permiten\u00a0un bajo nivel de circulaci\u00f3n viral.<\/p>\n<p>Por lo general, si no se toman medidas, el virus puede\u00a0circular durante a\u00f1os o de manera indefinida en la granja, de forma que, peri\u00f3dicamente,\u00a0aparecer\u00e1n brotes cl\u00ednicos.[\/vc_column_text]<div class=\"single_image wpb_content_element align-left  animate image_box_rounded image_zoom \" data-animation=\"fade-in\" data-delay=\"300\"><a href=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja.jpg\" class=\"prettyPhoto\" rel=\"prettyPhoto[image]\"><img loading=\"lazy\" decoding=\"async\" width=\"1400\" height=\"1138\" src=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja.jpg\" class=\"attachment-full\" alt=\"\" title=\"Circulacion-del-virus-del-PRRS-dentro-de-una-granja\" srcset=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja.jpg 1400w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja-300x244.jpg 300w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja-768x624.jpg 768w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja-1024x832.jpg 1024w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja-750x610.jpg 750w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Circulacion-del-virus-del-PRRS-dentro-de-una-granja-1140x927.jpg 1140w\" sizes=\"auto, (max-width: 1400px) 100vw, 1400px\" \/><\/a><\/div>[vc_column_text][\/vc_column_text][vc_column_text]En general, se pueden considerar tres situaciones diferentes:<\/p>\n<h2>1. Primera introducci\u00f3n del virus en una granja negativa<\/h2>\n<p>Lo m\u00e1s probable es que\u00a0la infecci\u00f3n provoque un brote grave (consulte la informaci\u00f3n sobre el cuadro\u00a0reproductivo en el cap\u00edtulo \u201cPatogenia, lesiones y signos cl\u00ednicos\u201d).<\/p>\n<p>Abortos en\u00a0oleadas (\u00faltimo tercio de la gestaci\u00f3n) durante meses, partos tempranos, lechones\u00a0nacidos d\u00e9biles, splay-leg, aumento de la mortalidad antes del destete, etc.<\/p>\n<p>En\u00a0explotaciones peque\u00f1as, la infecci\u00f3n puede ser autolimitante. Sin embargo, tal\u00a0y como se describi\u00f3 anteriormente, en la mayor\u00eda de los casos el virus continuar\u00e1\u00a0circulando.<\/p>\n<p>En estas circunstancias, la diseminaci\u00f3n del virus en las fases de\u00a0transici\u00f3n y engorde suele ser muy r\u00e1pida.<\/p>\n<h2>2. Introducci\u00f3n de una nueva cepa del virus en una granja positiva<\/h2>\n<p>Desde ning\u00fan\u00a0efecto a un brote grave. Depender\u00e1 de la cepa, el nivel de inmunizaci\u00f3n de la\u00a0poblaci\u00f3n y la presencia de subpoblaciones negativas.<\/p>\n<h2>3. Recirculaci\u00f3n o reaparici\u00f3n de la cepa anteriormente presente en la granja<\/h2>\n<p>Probablemente, deterioro temporal de los par\u00e1metros productivos y reproductivos.\u00a0Nuevamente, la presencia de subpoblaciones negativas puede ser crucial.[\/vc_column_text]<div class=\"single_image wpb_content_element align-left  animate image_box_rounded image_zoom \" data-animation=\"fade-in\" data-delay=\"300\"><a href=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja.jpg\" class=\"prettyPhoto\" rel=\"prettyPhoto[image]\"><img loading=\"lazy\" decoding=\"async\" width=\"1400\" height=\"1138\" src=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja.jpg\" class=\"attachment-full\" alt=\"\" title=\"Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja\" srcset=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja.jpg 1400w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja-300x244.jpg 300w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja-768x624.jpg 768w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja-1024x832.jpg 1024w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja-750x610.jpg 750w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2021\/03\/Principales-factores-involucrados-en-el-mantenimiento-de-la-infeccion-del-virus-del-PRRS-en-una-granja-1140x927.jpg 1140w\" sizes=\"auto, (max-width: 1400px) 100vw, 1400px\" \/><\/a><\/div>[vc_column_text el_class=\u00bbaviso\u00bb]<\/p>\n<hr \/>\n<p style=\"text-align: center;\">\u00a9 Laboratorios Hipra, S.A. 2026. Reservados todos los derechos.<br \/>\nNinguna parte de este sitio web o cualquiera de sus contenidos puede ser reproducida, copiada, modificada o adaptada, sin el consentimiento previo por escrito de HIPRA.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row top_padding=\u00bb30&#8243; row_id=\u00bbreferencias\u00bb][vc_column width=\u00bb1\/1&#8243;]<div class=\"toggle\"><div class=\"toggle-title \"><i class='fa fal fa-book'><\/i>Referencias<\/div><div class=\"toggle-inner\"><p>\n<ul>\n<li>Albina E. Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview. Vet Microbiol. 1997, 55:309-16.<\/li>\n<li>Albina E, Carrat C, Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J Interferon Cytokine Res. 1998, 18:485-90.<\/li>\n<li>Allende R, Laegreid WW, Kutish GF, Galeota JA, Wills RW, Osorio FA. 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Vet Res. 2000, 31:71.<\/li>\n<li>Benfield DA, Nelson C, Steffen M, Rowland RRR. Transmission of PRRSV by artificial insemination using extended semen seeded with different concentrations of PRRSV. Proceeding of the American Association of Swine Practitioners. 2000:405-408.<\/li>\n<li>Bierk MD, Dee SA, Rossow KD, Otake S, Collins JE, Molitor TW. Transmission of porcine reproductive and respiratory syndrome virus from persistently infected sows to contact controls. Can J Vet Res. 2001, 65:261-6.<\/li>\n<li>Blaha T. The \u00abcolorful\u00bb epidemiology of PRRS. Vet Res. 2000, 31:77-83.<\/li>\n<li>Brockmeier SL, Lager KM. Experimental airborne transmission of porcine reproductive and respiratory syndrome virus and Bordetella bronchiseptica. Vet Microbiol. 2002, 89:267-75.<\/li>\n<li>Brito B, Dee SA, Wayne S, Alvarez J, Perez A. Genetic diversity of PRRS virus collected from air samples in four different regions of concentrated swine production during a high incidence season. Viruses. 2014, 6:4424-36.<\/li>\n<li><a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Charpin%20C%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Charpin\u00a0C<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Mah%C3%A9%20S%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Mah\u00e9 S<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Keranflec%27h%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Keranflec&#8217;h A<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Belloc%20C%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Belloc C<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Cariolet%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Cariolet R<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Le%20Potier%20MF%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Le Potier MF<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Rose%20N%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23061672\" target=\"_blank\" rel=\"noopener\">Rose N<\/a>. Infectiousness of pigs infected by the\u00a0Porcine Reproductive and Respiratory Syndrome\u00a0virus (PRRSV) is time-dependent. <a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=charpin+prrs\" target=\"_blank\" rel=\"noopener\">Vet Res.<\/a>2012, 43:69.<\/li>\n<li>Cho JG, Dee SA, Deen J, Guedes A, Trincado C, Fano E, Jiang Y, Faaberg K, Collins JE, Murtaugh MP, Joo HS. Evaluation of the effects of animal age, concurrent bacterial infection, and pathogenicity of porcine reproductive and respiratory syndrome virus on virus concentration in pigs. Am J Vet Res. 2006, 67:489-93.<\/li>\n<li>Cho JG, Dee SA. Porcine reproductive and respiratory syndrome virus. Theriogenology. 2006, 66:655-62.<\/li>\n<li>Cho JG, Deen J, Dee SA. Influence of isolate pathogenicity on the aerosol transmission of Porcine reproductive and respiratory syndrome virus. Can J Vet Res. 2007, 71:23-7.<\/li>\n<li>Christianson WT, Choi CS, Collins JE, Molitor TW, Morrison RB, Joo HS. Pathogenesis of porcine reproductive and respiratory syndrome virus infection in mid-gestation sows and fetuses. Can J Vet Res. 1993, 57:262-8.<\/li>\n<li>Christopher-Hennings J, Nelson EA, Hines RJ, Nelson JK, Swenson SL, Zimmerman JJ, Chase CL, Yaeger MJ, Benfield DA. Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars. J Vet Diagn Invest. 1995, 7:456-64.<\/li>\n<li>Christopher-Hennings J, Nelson EA, Nelson JK, Hines RJ, Swenson SL, Hill HT, Zimmerman JJ, Katz JB, Yaeger MJ, Chase CC, et al. Detection of porcine reproductive and respiratory syndrome virus in boar semen by PCR. J Clin Microbiol. 1995, 33:1730-4.<\/li>\n<li>Christopher-Hennings J, Nelson EA, Benfield DA. Detecting PRRSV in boar semen. Swine Health and Production. 1996, 4:37-9.<\/li>\n<li>Christopher-Hennings J, Nelson EA, Nelson JK, Benfield DA. Effects of a modified-live virus vaccine against porcine reproductive and respiratory syndrome in boars. Am J Vet Res. 1997, 58:40-5.<\/li>\n<li>Christopher-Hennings J. The pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV) in the boar. Vet Res. 2000, 31:57-8.<\/li>\n<li>Christopher-Hennings J. Monitoring for porcine reproductive and respiratory syndrome virus (PRRSV) in the boar stud. J Swine Health Prod. 2001, 9:186-8.<\/li>\n<li>Christopher-Hennings J, Holler LD, Benfield DA, Nelson EA. Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J Vet Diagn Invest. 2001, 13:133-42.<\/li>\n<li>Corzo CA, Mondaca E, Wayne S, Torremorell M, Dee S, Davies P, Morrison RB. Control and elimination of porcine reproductive and respiratory syndrome virus. Virus Res. 2010, 154:185-92.<\/li>\n<li>Cutler TD, Wang C, Hoff SJ, Kittawornrat A, Zimmerman JJ. Median infectious dose (ID\u2085\u2080) of porcine reproductive and respiratory syndrome virus isolate MN-184 via aerosol exposure. Vet Microbiol. 2011, 151:229-37.<\/li>\n<li>Dee SA, Joo HS. Prevention of the spread of porcine reproductive and respiratory syndrome virus in endemically infected pig herds by nursery depopulation. Vet Rec. 1994, 135:6-9.<\/li>\n<li>Dee SA, Deen J, Rossow K, Wiese C, Otake S, Joo HS, Pijoan C. Mechanical transmission of porcine reproductive and respiratory syndrome virus throughout a coordinated sequence of events during cold weather. Can J Vet Res. 2002, 66:232-9.<\/li>\n<li>Dee S, Deen J, Rossow K, Weise C, Eliason R, Otake S, Joo HS, Pijoan C. Mechanical transmission of porcine reproductive and respiratory syndrome virus throughout a coordinated sequence of events during warm weather. Can J Vet Res. 2003, 67:12-9.<\/li>\n<li>Dee SA, Deen J, Otake S, Pijoan C. An experimental model to evaluate the role of transport vehicles as a source of transmission of porcine reproductive and respiratory syndrome virus to susceptible pigs. Can J Vet Res. 2004, 68:128-33.<\/li>\n<li>Dee SA, Martinez BC, Clanton C. Survival and infectivity of porcine reproductive and respiratory syndrome virus in swine lagoon effluent. Vet Rec. 2005, 156:56-7.<\/li>\n<li>Dee SA, Cano JP, Spronk G, Reicks D, Ruen P, Pitkin A, Polson D. Evaluation of the long-term effect of air filtration on the occurrence of new PRRSV infections in large breeding herds in swine-dense regions. Viruses. 2012, 4:654-62.<\/li>\n<li>De Jong MC, Kimman TG. Experimental quantification of vaccine-induced reduction in virus transmission.\u00a0Vaccine.\u00a01994, 12:761\u2013766.<\/li>\n<li>DiekmannO, Heesterbeek JA, Metz JA. <a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+2117040\" target=\"_blank\" rel=\"noopener\">On the definition and the computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations.<\/a> J Math Biol.\u00a01990, 28:365-82.Duan X, Nauwynck HJ, Pensaert MB. Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Microbiol. 1997, 56:9-19.<\/li>\n<li>Goldberg TL, Lowe JF, Milburn SM, Firkins LD. Quasispecies variation of porcine reproductive and respiratory syndrome virus during natural infection. Virology. 2003, 317:197-207.<\/li>\n<li>Guarino H, Cox RB, Goyal SM, Patnayak DP. Survival of Porcine Reproductive and Respiratory Syndrome Virus in Pork Products. Food Environ Virol. 2013 Jun 13.<\/li>\n<li>Hall W, Neumann E. Fresh Pork and Porcine Reproductive and Respiratory Syndrome Virus: Factors Related to the Risk of Disease Transmission. Transbound Emerg Dis. 2013 Sep 10.<\/li>\n<li>Hermann JR, Mu\u00f1oz-Zanzi CA, Roof MB, Burkhart K, Zimmerman JJ. Probability of porcine reproductive and respiratory syndrome (PRRS) virus infection as a function of exposure route and dose. Vet Microbiol. 2005, 110:7-16.<\/li>\n<li>Hermann JR, Hoff S, Mu\u00f1oz-Zanzi C, Yoon KJ, Roof M, Burkhardt A, Zimmerman J. Effect of temperature and relative humidity on the stability of infectious porcine reproductive and respiratory syndrome virus in aerosols. Vet Res. 2007, 38:81-93.<\/li>\n<li>Hooper CC, Van Alstine WG, Stevenson GW, Kanitz CL. Mice and rats (laboratory and feral) are not a reservoir for PRRS virus. J Vet Diagn Invest. 1994, 6:13-5.<\/li>\n<li>Kappes MA, Faaberg KS. PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity. Virology. 2015, 479-480:475-86.<\/li>\n<li>Karniychuk UU, Saha D, Geldhof M, Vanhee M, Cornillie P, Van den Broeck W, Nauwynck HJ. Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites. Microb Pathog. 2011, 51:194-202.<\/li>\n<li>Karniychuk UU, Nauwynck HJ. Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection. Vet Res. 2013, 44:95.<\/li>\n<li>Klinkenberg, D, de Bree, J, Laevens, H, de Jong, MC, Within- and<br \/>\nbetween-pen transmission of Classical Swine Fever Virus: a new method to<br \/>\nestimate the basic reproduction ratio from transmission experiments. Epidemiol. Infect. 2002, 128: 293\u2013299.Kristensen CS, B\u00f8tner A, Takai H, Nielsen JP, Jorsal SE. Experimental airborne transmission of PRRS virus. Vet Microbiol. 2004, 99:197-202.<\/li>\n<li>Labarque GG, Nauwynck HJ, Van Reeth K, Pensaert MB. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J Gen Virol. 2000, 81:1327-34.<\/li>\n<li>Larochelle R1, D&#8217;Allaire S, Magar R. Molecular epidemiology of porcine reproductive and respiratory syndrome virus (PRRSV) in Qu\u00e9bec. Virus Res. 2003, 96:3-14.<\/li>\n<li>Le Potier MF, Blanquefort P, Morvan E, Albina E. Results of a control programme for the porcine reproductive and respiratory syndrome in the French &#8216;Pays de la Loire&#8217; region. Vet Microbiol. 1997, 55:355-60.<\/li>\n<li>Magar R, Larochelle R, Dea S, Gagnon CA, Nelson EA, Christopher-Hennings J, Benfield DA. Antigenic comparison of Canadian and US isolates of porcine reproductive and respiratory syndrome virus using monoclonal antibodies to the nucleocapsid protein. 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J Virol. 2014, 88:3170-81.<\/li>\n<li>Mondaca-Fern\u00e1ndez E, Meyns T, Mu\u00f1oz-Zanzi C, Trincado C, Morrison RB. <a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+17479780\" target=\"_blank\" rel=\"noopener\">Experimental quantification of the transmission of\u00a0Porcine reproductive and respiratory syndrome<\/a> Can J Vet Res. 2007, 71:157-60.<\/li>\n<li>Nodelijk\u00a0G,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=de%20Jong%20MC%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">de Jong MC<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Van%20Nes%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">Van Nes A<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Vernooy%20JC%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">Vernooy JC<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Van%20Leengoed%20LA%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">Van Leengoed LA<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Pol%20JM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">Pol JM<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Verheijden%20JH%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=10722145\" target=\"_blank\" rel=\"noopener\">Verheijden JH<\/a>. Introduction, persistence and fade-out of\u00a0porcine reproductive and respiratory syndrome\u00a0virus in a Dutch breeding herd: a mathematical analysis. <a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=nodelijk+prrs+2000\" target=\"_blank\" rel=\"noopener\">Epidemiol Infect.<\/a>2000,\u00a0124: 173-82.<\/li>\n<li><a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Nodelijk%20G%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">Nodelijk\u00a0G<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=de%20Jong%20MC%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">de Jong MC<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=van%20Leengoed%20LA%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">van Leengoed LA<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Wensvoort%20G%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">Wensvoort G<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Pol%20JM%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">Pol JM<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Steverink%20PJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">Steverink PJ<\/a>,\u00a0<a href=\"https:\/\/xpv.uab.cat\/pubmed\/,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+?term=Verheijden%20JH%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=11395197\" target=\"_blank\" rel=\"noopener\">Verheijden JH<\/a>. 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Vet Microbiol. 1997, 55:187-96.<\/li>\n<\/ul>\n<\/p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<div style=\"text-align:center\" class=\"yasr-auto-insert-visitor\"><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=\u00bb1\/1&#8243;][vc_column_text el_class=\u00bbintro\u00bb]Las consecuencias de una infecci\u00f3n por el virus del PRRS en una granja depender\u00e1n\u00a0principalmente de la virulencia de la cepa y del estado previo de inmunizaci\u00f3n.[\/vc_column_text][vc_column_text]Una vez que se introduce el virus del PRRS en una granja, este tender\u00e1 a circular\u00a0indefinidamente. La eliminaci\u00f3n espont\u00e1nea puede ocurrir, especialmente en granjas\u00a0peque\u00f1as, pero es muy rara. La presencia de una infecci\u00f3n persistente en animales\u00a0portadores, la presencia de subpoblaciones negativas en el hato reproductor y\/o un flujo\u00a0continuo de animales susceptibles pueden perpetuar la infecci\u00f3n: reposici\u00f3n negativa\u00a0insuficientemente inmunizada, nacimiento de lechones de cerdas seronegativas, p\u00e9rdida\u00a0de inmunidad pasiva en lechones o p\u00e9rdida de inmunidad activa en cerdos previamente\u00a0infectados. Por ejemplo, la seroprevalencia en cerdas durante un brote agudo nunca\u00a0alcanza el 100%. As\u00ed, un porcentaje variable de cerdas se escapan de la infecci\u00f3n inicial,\u00a0pero m\u00e1s tarde seroconvierten, lo que indica que las subpoblaciones negativas permiten\u00a0un bajo nivel de circulaci\u00f3n viral. Por lo general, si no se toman medidas, el virus puede\u00a0circular durante a\u00f1os o de manera indefinida en la granja, de forma que, peri\u00f3dicamente,\u00a0aparecer\u00e1n brotes cl\u00ednicos.[\/vc_column_text][vc_column_text][\/vc_column_text][vc_column_text]En general, se pueden considerar tres situaciones diferentes: 1. Primera introducci\u00f3n del virus en una granja negativa Lo m\u00e1s probable es que\u00a0la infecci\u00f3n provoque un brote grave (consulte la informaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":19,"featured_media":17056,"parent":20725,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_cbd_carousel_blocks":"[]","yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"Product","footnotes":""},"categories":[],"tags":[],"class_list":["post-20711","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yasr_visitor_votes":{"number_of_votes":0,"sum_votes":0,"stars_attributes":{"read_only":false,"span_bottom":false}},"_links":{"self":[{"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/pages\/20711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/comments?post=20711"}],"version-history":[{"count":3,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/pages\/20711\/revisions"}],"predecessor-version":[{"id":20898,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/pages\/20711\/revisions\/20898"}],"up":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/pages\/20725"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/media\/17056"}],"wp:attachment":[{"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/media?parent=20711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/categories?post=20711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prrscontrol.com\/es\/wp-json\/wp\/v2\/tags?post=20711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}