{"id":27092,"date":"2025-03-05T20:42:22","date_gmt":"2025-03-05T20:42:22","guid":{"rendered":"https:\/\/prrscontrol.com\/pigs-vaccinated-with-a-prrsv1-mlv-developed-potent-immunity-against-japanese-prrsv2-strains\/"},"modified":"2025-03-05T20:55:21","modified_gmt":"2025-03-05T20:55:21","slug":"immunity-against-japanese-prrsv2-strains","status":"publish","type":"post","link":"https:\/\/prrscontrol.com\/zh-hant\/immunity-against-japanese-prrsv2-strains\/","title":{"rendered":"\u514d\u75abPRRS1\u6d3b\u6bd2\u6e1b\u6bd2\u75ab\u82d7\u7684\u8c6c\u96bb\uff0c\u7522\u751f\u5f37\u5927\u53ef\u5c0d\u6297\u65e5\u672cPRRS2\u672c\u571f\u75c5\u6bd2\u682a\u7684\u514d\u75ab\u53cd\u61c9"},"content":{"rendered":"<h1 style=\"font-weight: 400;\"><strong>\u514d\u75abPRRS1\u6d3b\u6bd2\u6e1b\u6bd2\u75ab\u82d7\u7684\u8c6c\u96bb\uff0c\u7522\u751f\u5f37\u5927\u53ef\u5c0d\u6297\u65e5\u672cPRRS2\u672c\u571f\u75c5\u6bd2\u682a\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/strong><\/h1>\n<div>\n<p style=\"font-weight: 400;\">\u6539\u7de8\u81ea Salvador Romero \u7b49\u4eba\u65bcIPVS 2024\u6703\u8b70\u4e0a\u7684\u767c\u8868\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<h2>\u524d\u8a00<\/h2>\n<p>\u6d3b\u6bd2\u6e1b\u6bd2\u75ab\u82d7\uff08MLV\uff09\u4ecd\u7136\u662f\u4fdd\u8b77\u8c6c\u96bb\u514d\u65bc\u8c6c\u7e41\u6b96\u8207\u547c\u5438\u7d9c\u5408\u75c7\uff08PRRS\uff09\u4fb5\u5bb3\u7684\u95dc\u9375\u5de5\u5177\uff0c\u800cPRRS\u88ab\u8a8d\u70ba\u662f\u8c6c\u5834\u4e2d\u640d\u5931\u6700\u5927\u7684\u75be\u75c5\u4e4b\u4e00\u3002\u7d30\u80de\u6027\u514d\u75ab\u53cd\u61c9\uff08CMI\uff09\u5728MLV\u75ab\u82d7\u63a5\u7a2e\u5f8c\u626e\u6f14\u8457\u6838\u5fc3\u89d2\u8272\uff0c\u56e0\u70ba\u5b83\u8ca0\u8cac\u7e2e\u77ed\u75c5\u6bd2\u8840\u75c7\u7684\u6301\u7e8c\u6642\u9593\uff0c\u9032\u800c\u9650\u5236\u75c5\u6bd2\u7684\u64f4\u6563<sup>1,2<\/sup>\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7531\u4e2d\u548c\u6297\u9ad4\uff08NA\uff09\u63d0\u4f9b\u7684\u9ad4\u6db2\u6027\u514d\u75ab\u96d6\u7136\u4e5f\u81f3\u95dc\u91cd\u8981\uff0c\u4f46\u5176\u8a98\u767c\u6642\u9593\u8f03\u4e45\u4e14\u96e3\u9054\u5230\u9ad8\u6297\u9ad4\u529b\u50f9<sup>3,4<\/sup>\u3002<\/p>\n<p>\u8003\u91cf\u5230\u9019\u4e9b\u56e0\u7d20\uff0c\u8a55\u4f30PRRS MLV\u75ab\u82d7\u6240\u80fd\u8a98\u767c\u7684CMI\u548cNA\uff0c\u5c0d\u65bc\u5224\u65b7\u662f\u5426\u80fd\u5920\u5c0d\u6297\u5834\u5167\u75c5\u6bd2\u682a\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<p>\u6700\u8fd1\uff0cSalvador Romero\u548c\u540c\u4e8b\u7b49\u4eba<sup>5<\/sup>\uff0c\u9032\u884cUNISTRAIN\u00ae PRRS\uff08PRRSV1 MLV\uff0cHIPRA\uff09\u6240\u8a98\u5c0e\u7522\u751f\u7684NA\u548cCMI\u5c0d\u65e5\u672cPRRSV2\u672c\u571f\u682a\u611f\u67d3\u4fdd\u8b77\u6027\u7684\u8a55\u4f30\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u6750\u6599\u548c\u65b9\u6cd5<\/h2>\n<p>\u982d\u7121PRRS\u6297\u9ad4\u8c6c\u96bb\u5728\u5169\u9031\u9f61\u9f61\u63a5\u7a2eUNISTRAIN\u00ae PRRS\uff0c\u4e26\u5728\u63a5\u7a2e\u5f8c\u56db\u9031\u6536\u96c6\u9031\u908a\u8840\u6db2\u55ae\u6838\u7d30\u80de\uff08PBMC\uff09\u548c\u8840\u6e05\u3002<\/p>\n<p>CMI\u548cNA\u662f\u4ee5\u4e03\u500b\u65e5\u672cPRRSV2\u672c\u571f\u682a\u9032\u884c\u8a55\u4f30\uff08Nagasaki11-14\u3001P192-5\u3001EDRD1\u3001KU-27-156K\u3001338\u3001345\u3001348\uff09(\u88681)<\/p>\n<ul>\n<li>CMI\u662f\u4f7f\u7528ELISPOT\u5206\u6790\u9032\u884cIFN-\u03b3-SC(IFN-\u03b3\u5206\u6ccc\u7d30\u80de) \u8a55\u4f30<sup>6<\/sup>\u3002<\/li>\n<li>\u9ad4\u6db2\u6027\u514d\u75ab\u4ee5\u75c5\u6bd2\u4e2d\u548c\u8a66\u9a57\u9032\u884c\u8a55\u4f30\u3002<\/li>\n<\/ul>\n<p>VP-046\u682a\uff08\u75ab\u82d7\u540c\u6e90\u75c5\u6bd2\u682a\uff09\u88ab\u4e00\u540c\u7d0d\u5165\u6e2c\u8a66\uff0c\u5176\u523a\u6fc0\u4f5c\u7528\u4f5c\u70ba\u5c0d\u6bd4\uff0c\u4e26\u901a\u904eKruskal-Wallis\u6e2c\u8a66\uff08\u975e\u53c3\u6578\uff09\u8207\u65e5\u672c\u682a\u9032\u884c\u6bd4\u8f03\u3002<\/p>\n<div id=\"attachment_27049\" style=\"width: 660px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-27049\" class=\"wp-image-27048\" src=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin.jpg\" alt=\"Origin of the PRRSV strains\" width=\"650\" height=\"388\" srcset=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin.jpg 1146w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin-300x179.jpg 300w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin-1024x611.jpg 1024w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin-768x458.jpg 768w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin-750x448.jpg 750w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/prrsv-strain-origin-1140x680.jpg 1140w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/a><p id=\"caption-attachment-27049\" class=\"wp-caption-text\">\u88681 \u2013 \u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684PRRSV\u682a\u4f86\u6e90\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<h2>\u7d50\u679c<\/h2>\n<p>\u63a5\u7a2e\u75ab\u82d7\u7684\u52d5\u7269\u5c0d\u6240\u6709\u5206\u6790\u7684\u65e5\u672cPRRSV2\u672c\u571f\u682a\u8a98\u767c\u4e86IFN-\u03b3-SC\u53cd\u61c9\uff08\u88682\uff09\u3002\u9019\u4e9b\u53cd\u61c9\u8207\u75ab\u82d7\u682a\u7684\u53cd\u61c9\u76f8\u7576\uff08\u9664\u4e86Nagasaki11-14\uff09\uff0c\u986f\u793a\u51fa\u76f8\u7b49\u7684\u7d30\u80de\u6027\u53cd\u61c9\u3002\u6b64\u5916\uff0c70-100%\u63a5\u7a2e\u8c6c\u96bb\u5728\u6bcf\u500b\u75c5\u6bd2\u682a\u7684\u523a\u6fc0\u4e0b\u5747\u6709\u53cd\u61c9\u3002<\/p>\n<div id=\"attachment_27057\" style=\"width: 660px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-27057\" class=\"wp-image-27056\" src=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay.jpg\" alt=\"Results of ELISPOT Assay\" width=\"650\" height=\"317\" srcset=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay.jpg 1396w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay-300x146.jpg 300w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay-1024x499.jpg 1024w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay-768x374.jpg 768w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay-750x365.jpg 750w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/Results-of-ELISPOT-Assay-1140x555.jpg 1140w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/a><p id=\"caption-attachment-27057\" class=\"wp-caption-text\">\u88682 \u2013 ELISPOT\u5206\u6790\u7d50\u679c\u3002<br \/>*\u5206\u6ccc\u7d30\u80de\u5e73\u5747\u503c<br \/>**\u672a\u53cd\u61c9\u8005\uff1a&lt;5\u500b\u6591\u9ede&#8221;s<\/p><\/div>\n<p>\u63a5\u7a2e\u5f8c\uff0c\u8c6c\u96bb\u5c0d\u65bc\u4e09\u500b\u65e5\u672c\u682a\uff08Nagasaki11-14\u3001EDRD1\u548c345\uff09\u7522\u751f\u4e86NA\u3002\u7136\u800c\uff0c\u5118\u7ba1\u5c0d\u9019\u4e9b\u75c5\u6bd2\u682a\u7684CMI\u76f8\u7576\u986f\u8457\uff0c\u4f46P192-5\u3001PRRSKU-27-156K\u3001338\u548c348\u682a\u7684NA\u7d50\u679c\u4e26\u4e0d\u78ba\u5207\uff08\u88683\uff09\u3002<\/p>\n<div id=\"attachment_27066\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/neutralization-prrsv.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-27066\" class=\"wp-image-27065\" src=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/neutralization-prrsv.jpg\" alt=\"Serum Neutralization Index\" width=\"400\" height=\"353\" srcset=\"https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/neutralization-prrsv.jpg 762w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/neutralization-prrsv-300x265.jpg 300w, https:\/\/prrscontrol.com\/wp-content\/uploads\/2025\/03\/neutralization-prrsv-750x661.jpg 750w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-27066\" class=\"wp-caption-text\">\u88683 \u2013 \u6bcf\u500b\u6e2c\u8a66\u75c5\u6bd2\u682a\u7684\u8840\u6e05\u4e2d\u548c\u6307\u6578\uff08SNI\uff09\u3002<br \/>*SNI = \u7121\u8840\u6e05\u7684\u75c5\u6bd2\u6ef4\u5ea6 \/ \u8207\u6297\u8840\u6e05\u57f9\u990a\u7684\u75c5\u6bd2\u6ef4\u5ea6\u3002<br \/>Log SNI \u5927\u65bc\u6216\u7b49\u65bc 2 \u5247\u78ba\u8a8d\u8207\u6e2c\u8a66\u75c5\u6bd2\u7522\u751f\u53cd\u61c9\u3002<\/p><\/div>\n<p>&nbsp;<\/p>\n<h2>\u7d50\u679c\u8207\u8a0e\u8ad6<\/h2>\n<p>\u5c0d\u65bcPRRS\uff0c\u65bd\u6253\u4e00\u5291MLV\u5f8c\u6240\u7522\u751f\u7684NA\u662f\u6709\u9650\u7684\uff0c\u5176\u8a98\u767c\u6642\u9593\u8f03\u6162\u4e14\u672a\u9054\u5230\u9ad8\u6297\u9ad4\u529b\u50f9\u3002\u56e0\u6b64\uff0cPRRS\u75ab\u82d7\u7522\u751f\u7684CMI\u5728\u4fdd\u8b77\u514d\u53d7\u75c5\u6bd2\u611f\u67d3\u626e\u6f14\u8457\u91cd\u8981\u89d2\u8272\u3002\u672c\u7814\u7a76\u6240\u7372\u5f97\u7684\u7d50\u679c\u78ba\u8a8d\u4e86UNISTRAIN\u00ae PRRS\u53ef\u4ee5\u5c0d40%\u7684\u6e2c\u8a66\u75c5\u6bd2\u682a\u7522\u751fNA\u3002\u95dc\u65bcCMI\uff0c\u6b64\u75ab\u82d7\u5c0d\u5e7e\u4e4e\u6240\u6709\u7684\u6e2c\u8a66\u75c5\u6bd2\u682a\u90fd\u8a98\u767c\u4e86\u5f37\u5927\u7684\u7d30\u80de\u6027\u514d\u75ab\u53cd\u61c9\u3002\u56e0\u6b64\uff0cUNISTRAIN\u00ae PRRS\u53ef\u4ee5\u662f\u4e00\u500b\u63a7\u5236\u65e5\u672cPRRSV2\u672c\u571f\u682a\u7684\u597d\u9078\u64c7<\/p>\n<p>\u5982\u679c\u60a8\u60f3\u95b1\u8b80\u66f4\u591a\u6709\u95dc PRRS \u7684\u51fa\u7248\u7269\uff1a<a href=\"https:\/\/prrscontrol.com\/publications\/\">PRRS Control Publications<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u53c3\u8003\uff1a<\/p>\n<h6><em>1. D\u00edaz I, Gimeno M, Darwich L, Navarro N, Kuzemtseva L, L\u00f3pez S, Galindo I, Segal\u00e9s J, Mart\u00edn M, Pujols J, Mateu E. Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection. Vet Res. 2012 Apr 19;43(1):30. doi: 10.1186\/1297-9716-43-30. <\/em><\/h6>\n<h6><em>2. Meier WA, Husmann RJ, Schnitzlein WM, Osorio FA, Lunney JK, Zuckermann FA. Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to Porcine Reproductive and Respiratory Syndrome Virus. Veterinary Immunology and Immunopathology. 2004 (102), 299:314 doi: 10.1016\/j.vetimm.2004.09.012.<\/em><\/h6>\n<h6><em>3. D\u00edaz I, Darwich L, Pappaterra G, Pujols J, Mateu E. Different European-type vaccines against Porcine Reproductive and Respiratory Syndrome virus have different immunological properties and confer different protection to pigs. 2006 August, 351 (2) 249:259 doi: 10.1016\/j.virol.2006.03.046.<\/em><\/h6>\n<h6><em>4. Zuckerman et al. (2007). Vet Microbiol 123, 69-85.<\/em><\/h6>\n<h6><em>5. Romero S, Fenech M, Miranda J, Ballar\u00e1 I, Shibata M. Pigs vaccinated with a PRRSV1 MLV developed potent immunity against Japanese PRRSV2 strains. 27th International Pig Veterinary Society Congress (2024). Leipzig, Germany<\/em><\/h6>\n<h6><em>6. D\u00edaz I, Mateu E. Use of ELISPOT and ELISA to evaluate IFN-y, IL-10 and IL-4 responses in conventional pigs. Veterinary Immunology and Immunopathology. 2005, 102 (1-2) 107:112 doi: 10.1016\/j.vetimm.2005.01.005.<\/em><\/h6>\n<div style=\"text-align:center\" class=\"yasr-auto-insert-visitor\"><\/div>","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\uff0cSalvador Romero\u548c\u540c\u4e8b\u7b49\u4eba\uff0c\u9032\u884cUNISTRAIN\u00ae PRRS\uff08PRRSV1 MLV\uff0cHIPRA\uff09\u6240\u8a98\u5c0e\u7522\u751f\u7684NA\u548cCMI\u5c0d\u65e5\u672cPRRSV2\u672c\u571f\u682a\u611f\u67d3\u4fdd\u8b77\u6027\u7684\u8a55\u4f30\u3002<\/p>\n","protected":false},"author":18,"featured_media":27057,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_cbd_carousel_blocks":"[]","yasr_overall_rating":0,"yasr_post_is_review":"","yasr_auto_insert_disabled":"","yasr_review_type":"","footnotes":""},"categories":[216,215],"tags":[220],"class_list":["post-27092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-216","category-215","tag-the-prrs-experts-answer-zh-hant"],"acf":[],"yasr_visitor_votes":{"number_of_votes":0,"sum_votes":0,"stars_attributes":{"read_only":false,"span_bottom":false}},"_links":{"self":[{"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/posts\/27092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/comments?post=27092"}],"version-history":[{"count":5,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/posts\/27092\/revisions"}],"predecessor-version":[{"id":27097,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/posts\/27092\/revisions\/27097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/media\/27057"}],"wp:attachment":[{"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/media?parent=27092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/categories?post=27092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prrscontrol.com\/zh-hant\/wp-json\/wp\/v2\/tags?post=27092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}