The PRRS virus



Recently, the International Committee on Taxonomy of Viruses has re-classified the two genotypes as two different species: PRRSV1 and PRRSV2.



Genomic organisation and virus structure

PRRS virus contains a non-segmented, single-stranded, positive-sense RNA genome. The RNA genome comprise at least ten open reading frames (ORFs); its size is approximately 15 kilobases.


Physical and chemical characteristics

As an RNA virus, it is considered that PRRS virus is a fairly labile virus in the environment. It is important to note that it is quickly inactivated by heat and drying. These facts should be taken account in the control of the disease and when samples are stored or sent to the lab.


Genetic diversity of the PRRS virus

Since the beginning, two PRRS virus genotypes were established: European or Type 1 (prototype Lelystad virus) and North American or Type 2 (prototype VR-2332). Interestingly, similarity between both prototype nucleotide sequences is as low as 55%. In fact, they have been recently considered as two different viral species: PRRSV1 and PRRSV2 (International Committee on Taxonomy of Viruses (ICTV).


Causes of PRRS virus genetic diversity

The PRRS virus genetic diversity is the result of mutation and selection, but also recombination: Random mutations: The PRRS virus mutation rate is assumed to be the highest so far for a virus, being up to 40 times higher than the mutation rates of well-known viruses, such as Avian influenza virus or Human immunodeficiency virus. Similarly to other RNA viruses, PRRS virus has an RNA polymerase that does not have the ability to correct the inherent common errors that occur during the transcription of RNA.


Consequences of PRRS virus genetic diversity

The high PRRS virus diversity has an important impact in diagnosis, immune response (vaccines, protection and immunopathogenesis), emergence of new strains, virulence, cell tropism, and epidemiology, among others.


Virulent strains

Since the disease emerged, PRRS virus has disseminated worldwide, gained genetic diversity and, in particular cases, increased its virulence. The basis for the virulence, however, remains unknown, despite being investigated with a variety of different approaches.


      I have read and agree to the Privacy Policy and Basic information on Data Protection.

      Informazioni di base sulla protezione dei dati personali:

      Titolare del trattamento: LABORATORIOS HIPRA, S.A.
      Finalità: Gestione del rapporto contrattuale e/o commerciale con HIPRA, incluso l’invio di notizie, promozioni e inviti a eventi sponsorizzati da HIPRA.
      Base giuridica: Esecuzione del rapporto contrattuale e del legittimo interesse di HIPRA.
      Destinatari: Terzi a cui HIPRA ha affidato servizi di cloud computing, sicurezza, auditing, mailing, supporto tecnico e informatico, nonché società del suo gruppo.
      Diritti: Richiedere l'accesso e la rettifica o la cancellazione dei dati personali e altri diritti come spiegato nelle informazioni aggiuntive. Puoi vedere le informazioni aggiuntive dettagliate sulla protezione dei dati nella nostra Informativa sulla privacy.

      Per ulteriori informazioni, puoi consultare le nostre informazioni dettagliate sulla Protezione dei dati.

      Basic Personal Data Protection information:

      Controller: LABORATORIOS HIPRA, S.A.
      Purposes: Managing the contractual and/or business relationship with HIPRA, including sending news, promotions and invitations to events sponsored by HIPRA.
      Lawful basis: Performance of the contractual relationship and HIPRA's legitimate Interest.
      Recipients: Third parties to which HIPRA has entrusted cloud computing, security, auditing, mailing, technical and computer support services, as well as companies in its group.
      Rights: Request access to and rectification or erasure of personal data and other rights as explained in the additional information. You can seeview the detailed additional information about data protection in our Privacy Policy.

      For further information, please check our detailed information on Data Protection.

      Información básica sobre protección de datos:

      Responsable del tratamiento: LABORATORIOS HIPRA, S.A.
      Propósitos: Gestionar la relación contractual y comercial con HIPRA, incluido el envío de noticias, promociones e invitaciones a eventos patrocinados por HIPRA.
      Fundamentos legales: Cumplimiento de la relación contractual e interés legítimo de HIPRA.
      Destinatarios: Terceros a los que HIPRA ha encargado las tareas de computación en la nube, seguridad, auditoría, correo, servicios de soporte técnico e informático, así como empresas de su grupo.
      Derechos: Solicitar el acceso y la rectificación o eliminación de los datos personales y otros derechos, tal como se explica en la información adicional. Puede ver la información adicional detallada sobre la protección de datos en nuestra Política de Privacidad.

      Para obtener más información, consulte nuestra información detallada sobre Protección de datos.