Is there any interference when administering PRRS and mycoplasma vaccines simultaneously? If yes, how long should I wait between administering?
Based on the data we have, there is no interference between simultaneously administering the PRRS and M. hyo vaccines as long as they are injected at independent points.
The simultaneous administration of modified live vaccines (MLV) and inactivated vaccines is a common practice in human medicine, and there is a multitude of literature that supports this evidence (1).
In human medicine, very few cases are described in which the simultaneous administration of two vaccines is not indicated, one of which would be in immunosuppressed people, such as in AIDS patients (infected by the HIV virus).
Mycoplama vaccine efficacy has been investigated in pigs previously infected with PRRS virus using a field strain; even in that case the vaccinated pigs developed a complete response to the vaccine (2).
However, I think it is important to specify that in cases in which the two vaccines are to be administered simultaneously using a single inoculation point, a commercial product designed for this particular purpose should be used, since it could happen that the adjuvant used in the M. hyo vaccine could partially or totally inactivate the PRRS vaccine.
The commercial products that allow their combined use have already been tested in this regard and therefore the efficacy of the two vaccines would not be affected.
If you want to know more about vaccine combination read out these publications:
- Neutralizing antibodies against PRRS virus in breeding pigs vaccinated with the combined administration of UNISTRAIN® PRRS and ERYSENG® PARVO
- Evaluation of the field safety and efficacy of the combination of UNISTRAIN® PRRS and AUSKIPRA® GN in sows.
- Viability of the PRRS virus contained in a live attenuated vaccine after its combination with an inactivated vaccine against Glässer disease
- Safety of the combination of UNISTRAIN®PRRS and GRIPORK® in a mass vaccination programme in sows
1. CDC. 2021. Timing and Spacing of Immunobiologics. General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). Updated August 5, 202.
2. Su-Jin Park et al. 2014. Interaction between single-dose Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus vaccines on dually infected pigs. Res Vet Sci. 2014 Jun; 96(3):516-22. doi: 10.1016/j.rvsc.2014.03.009. Epub 2014 Apr 2.
Marcovetgrup S.L. – Spain