What kind of immunological benefit can we expect through ID route?
The intradermal route is used in many vaccination protocols in humans and animals.
The notion behind the use of this route is to take advantage of the excellent antigen presenting capabilities of dermal dendritic cells as well as to reduce the interference created by the presence of maternally-derived antibodies (MDA) in very well irrigated tissues (such as the muscle).
In addition, the use of needleless devices for administering the vaccine improves animal welfare.
Intramuscular & intradermal vaccination
In the case of PRRSV vaccination it has been shown that the intradermal administration is at least equal to the intramuscular administration of live vaccines.
In principle, intradermal administration does not result in a faster priming of the immune response.
At present, there is no definitive evidence that with PRRSV intradermal vaccination there is less interference with the MDA.
A. Scollo et al., Livestock Science 233 (2020) 103939.
Busquet, M. et al.; IPVS & ESPHM Congress 2016.
Centre for Research on Animal Health (CReSA), Barcelona University (UAB) – Spain